i don't understand what the issue was with this study- it actually makes a huge amount of sense.
cyndi
Begin forwarded message:
From: FrancieS <francie@borzoi.com>Date: July 25, 2010 1:40:44 PM EDTSubject: [lowdosenaltrexone] New Study on Depression
I have a good friend in Sweden who has suffered from a serious back injury, followed by heavy pain killers, leading to a spiral down to horrible depression and the inability to function nearly at all.
At the same time that she was sinking, I was also going down hill with my MS and had no energy to offer to help her in any way.
In April 2009, I started on LDN and instantly found some joy and energy in life. After a short time, people noticed the difference in me and I was able to tell them about the use of LDN and how I think that it would be a boost for anybody.
Sussi was off of the opiod pain relievers and I convinced her to try LDN. After 5 months, she is a different person. She fought and won a claim for disability and is active on the newsgroups and has found purpose again in life.
Recently, she sent me a study that will be published soon from the Lund University Hospital in Sweden. It shows that those people who commit suicide have been found to have signs of inflammation in blood samples similar to those found after an ordinary viral infection.
"This supports the hypothesis that depression, or some forms of it may be a recurrent inflammatory disease similar to autoimmune diseases such as rheumatism, "said Lena Brundin, doctor of medical science."
I had originally thought that the reason that LDN raises the mood so much is that the release of endorphins is a natural mood elevator. What this says is that LDN may be doing more than that. It may be helping the immune system to clear inflammation that is leading to "a pathological behavior that is reminiscent of depression: fatigue, social avoidance, lack of concentration and lowered mood."
If some depressions are a result of recurring inflammation and LDN can help the body clear itself that inflammation, then it could be a real breakthrough in the study of depression.
This could also explain why one of the common symptoms of MS, chronic fatigue, fibromyalgia, etc. is depression. If that is the kind of depression that is brought on by systemic inflammation, then it is understandable that helping the immune system to clear the inflammation could help clear the depression.
Here is a link to the actual study:
<http://www.mynewsdesk.com/se/view/pressrelease/oekad-kunskap-om-depression-och-sjaelvmord-270045>
Here is a Google translation of that paper:
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Lund University Hospital
Increased knowledge about depression and suicide
February 5, 2009 09:02 CET
Depression is the leading cause of suicide. Recent scientific data suggest that while the prevalence of depression decreased slightly Lunda region.
Other researchers are seeking answers to the cause of suicidal behavior in the human immune system and its role in depression. Some other searches related to hereditary neurological diseases such as Huntington's disease.
At the monthly meeting this afternoon's Medical University Hospital in Lund presented both field studies and research at the molecular level.
More than 15 percent of all who suffer from depression commit suicide. But the world's oldest ongoing study of mental health, Lundby study, the number of stops at five percent.
- Previous studies of suicide risk is placed on people who had hospital treatment. The Lundby study is no such limitation. This includes all those diagnosed with depression and perhaps only received outpatient care, or none at all, "says psychiatrist Cecilia Mattisson.
With the help of record from records, hospitalization, death certificates and interviews, she has also identified the prevalence of depression among the population of parishes and Dalby Bonderup.
The 3563 persons included in the study have been divided into two groups, 1947-72 and 1972-97.
- New cases for women in the older group was 35.7 percent against 30.7 percent in the younger, "says Cecilia Mattisson.
In several studies of depression have noted signs of inflammation in blood samples from the patient. The same thing occurs after an ordinary viral infection that provides a pathological behavior that is reminiscent of depression: fatigue, social avoidance, lack of concentration and lowered mood.
- This supports the hypothesis that depression, or some forms of it may be a recurrent inflammatory disease similar to autoimmune diseases such as rheumatism, "said Lena Brundin, doctor of medical science that further training to be a specialist in psychiatry.
She has in her research focused on samples of cerebrospinal fluid from people who tried to kill himself. In total, 150 samples taken during 20 years at the University Hospital in Lund.
- We examine the samples for the presence of inflammatory substances that we know can affect nerve cells, which in turn influences behavior.
The molecular links are also visible in the deadly and hereditary Huntington's disease, dancing disease, characterized by involuntary movements.
The first symptoms is depression, anxiety and suicidal thoughts and debuting them up to fifteen years before illness.
- It is also Huntington a model for how we could treat depression, says Dr. Asa Petersén.
In cooperation with American scientists analyze her early changes in the brain by means of pictures taken with MRI. The main target is the hypothalamus, which controls emotions, among other things, weight and sleep.
The goal is to find biomarkers, and ultimately to either stop or delay the changes in the hypothalamus.
- To achieve this we work in large teams and in collaboration with geneticists and neurologists, "says Åsa Petersen.
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I would love to hear thoughts on this interesting connection between depression, inflammation and now LDN.
Francie
http://LDN-for-MS.com My story
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